| Home | Score | Away | League | Time (CST) |
|---|---|---|---|---|
| Orlando City B | 0:0 | Columbus Crew 2 | MLS Next Pro | 07:00 |
| Carolina Core | 1:0 | Huntsville City | MLS Next Pro | 06:00 |
| West Chester United | 1:2 | Lehigh Valley United | USL League Two | 07:00 |
| Deportes Puerto Montt | 1:0 | Deportes Concepción | Copa Chile | 08:00 |
| Ituano | 0:0 | Maranhão | Brazilian Serie C | 07:30 |
| Ypiranga | 1:1 | Confiança | Brazilian Serie C | 07:30 |
| New York Red Bulls II | 5:0 | Philadelphia Union II | MLS Next Pro | 07:00 |
| Weston FC | 2:3 | Lakeland United | USL League Two | 06:00 |
| Cusco | 1:2 | Cienciano | Peruvian Copa de la Liga | 07:00 |
| Tacoma Stars | 1:2 | West Seattle Junction | USL League Two | 07:00 |